SCNAC – XVIIIth Symposium on Chemistry of Nucleic Acid

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June 5, 2021Free Activators

05.09.2022 1 Comments

June 5, 2021Free Activators

October · Food Sovereignty as the Foundation · Millwork Conversations with Craig Moody · Mode Shift Omaha Coffee Chat & Bike Team Meeting · Library Garden. After the successful summer holiday football coaching at the Mile End facilities for young people we are doing a similar 3 day session during the. It is completely free and involves face to face training where young people learn how to umpire and score. As part of the course, they then get.

June 5, 2021Free Activators - suggest

TransRate: reference free quality assessment of de novo transcriptome assemblies

Abstract

TransRate is a tool for reference-free quality assessment of de novo transcriptome assemblies. Using only the sequenced reads and the assembly as input, we show multiple common artifacts of de novo transcriptome assembly can be readily detected. These include chimeras, structural errors, incomplete assembly and base errors. TransRate evaluates these errors to produce a diagnostic quality score for each contig and these contig scores are integrated to evaluate whole assemblies. Thus TransRate can be used for do novo assembly filtering and optimisation as well as comparison of assemblies generated using different methods from the same input reads. Applying the method to a dataset of published de novo transcriptome assemblies we deconstruct the contribution that assembly method, read length, read quantity, and read quality make to the accuracy of de novo transcriptome assemblies and reveal that variance in the quality of the input data explains 43% of the variance in the quality of published de novo transcriptome assemblies. As TransRate is reference-free it is suitable for assessment of assemblies of all types of RNA, including assemblies of long non-coding RNA, rRNA, mRNA, and mixed RNA samples.

Received July 2,
Accepted May 27,

Published by Cold Spring Harbor Laboratory Press

This manuscript is Open Access.

This article, published in Genome Research, is available under a Creative Commons License (Attribution International license), as described at www.buddysplantplus.com

@circulareconomy

###

Media Contacts: Samantha Kappalman

The Recycling Partnership

Skappalman@www.buddysplantplus.com

Objective

Metabolic syndrome (MetS) is defined as a complex of interrelated risk factors for type 2 diabetes and cardiovascular disease, including glucose intolerance, abdominal obesity, hypertension, and dyslipidemia. Studies using diffusion tensor imaging (DTI) have reported white matter (WM) microstructural abnormalities in MetS. However, interpretation of DTI metrics is limited primarily due to the challenges of modeling complex WM structures. The present study used fixel-based analysis (FBA) to assess the effect of MetS on the fiber tract-specific WM microstructure in older adults and its relationship with MetS-related measurements and cognitive and locomotor functions to better understand the pathophysiology of MetS.

Methods

Fixel-based metrics, including microstructural fiber density (FD), macrostructural fiber-bundle cross-section (FC), and a combination of FD and FC (FDC), were evaluated in 16 healthy controls (no components of MetS; four men; mean age, ± years), 57 individuals with premetabolic syndrome (preMetS; one or two components of MetS; 29 men; mean age, ± years), and 46 individuals with MetS (three to five components of MetS; 27 men; mean age, ± years) using whole-brain exploratory FBA. Tract of interest (TOI) analysis was then performed using TractSeg across 14 selected WM tracts previously associated with MetS. The associations between fixel-based metrics and MetS-related measurements, neuropsychological, and locomotor function tests were also analyzed in individuals with preMetS and MetS combined. In addition, tensor-based metrics (i.e., fractional anisotropy [FA] and mean diffusivity [MD]) were compared among the groups using tract-based spatial statistics (TBSS) analysis.

Results

In whole-brain FBA, individuals with MetS showed significantly lower FD, FC, and FDC compared with healthy controls in WM areas, such as the splenium of the corpus callosum (CC), corticospinal tract (CST), middle cerebellar peduncle (MCP), and superior cerebellar peduncle (SCP). Meanwhile, in fixel-based TOI, significantly reduced FD was observed in individuals with preMetS and MetS in the anterior thalamic radiation, CST, SCP, and splenium of the CC compared with healthy controls, with relatively greater effect sizes observed in individuals with MetS. Compared with healthy controls, significantly reduced FC and FDC were only demonstrated in individuals with MetS, including regions with loss of FD, inferior cerebellar peduncle, inferior fronto-occipital fasciculus, MCP, and superior longitudinal fasciculus part I. Furthermore, negative correlations were observed between FD and Brinkman index of cigarette consumption cumulative amount and between FC or FDC and the Trail Making Test (parts B–A), which is a measure of executive function, waist circumference, or low-density lipoprotein cholesterol. Finally, TBSS analysis revealed that FA and MD were not significantly different among all groups.

Conclusions

The FBA results demonstrate that substantial axonal loss and atrophy in individuals with MetS and early axonal loss without fiber-bundle morphological changes in those with preMetS within the WM tracts are crucial to cognitive and motor function. FBA also clarified the association between executive dysfunction, abdominal obesity, hyper-low-density lipoprotein cholesterolemia, smoking habit, and compromised WM neural tissue microstructure in MetS.

XVIII^th Symposium on Chemistry of Nucleic Acid Components

- Opening

- PL-1Tom Brown: Artificial nucleic acid backbones

- OCAfaf El-Sagheer: Artificial nucleic acid backbones: applications in Synthetic Biology

- OCJean-Louis Mergny: Quadruplexes & Infectious diseases

- Cofee Break

- EYIL-1Hana Cahova: Non-canonical RNA caps – their discovery and role

- OC Anais Depaix: Mono and dual labeling of RNA: application to mRNA as a biological tool

- OCMarcin Warminski: Quick access to nucleoside phosphoramidites with N-substituted nucleobases for the synthesis of RNA fragments containing post-transcriptional modifications and epitranscriptomic marks.

- OCAdam Mamot: Chemical and chemoenzymatic modification of RNA – an elegant synthesis of dually labeled mRNA probes

- OCMasayuki Tera: Ligand stabilization of G-quadruplex increases sensitivity to S1 nuclease

- Lunch

- PL-2Ronald Micura: A natural riboswitch scaffold with methyltransferase aktivity

- OCClaudia Höbartner: RNA-catalyzed RNA methylation by the methyltransferase ribozyme MTR1

- OCThomas Carell: The prebiotic origin of the RNA nucleosides and translation

- OCEnrico Cadoni: From G-Quadruplex to I-Motif Photo-alkylation, exploiting photosensitizer and ligand co-localization

- Cofee Break

- PL-3Oliver Seitz: Achieving true catalysis in nucleic acid-templated reactions

- OCMichael Smietana: Expanding DNA-based asymmetric catalysis

- OCChiara Figazzolo: Synthesis and characterization of a vancomycin-modified uridine to be included in aptamer selection

- OCMarek Ondruš: Enzymatic synthesis of hypermodified DNA polymers from DNA or RNA template

- Jena Bioscience Beer-party and Dinner

The AMSAT News Service bulletins are a free, weekly news and information service of AMSAT, The Radio Amateur Satellite Corporation. ANS publishes news related to Amateur Radio in Space including reports on the activities of a worldwide group of Amateur Radio operators who share an active interest in designing, building, launching and communicating through analog and digital Amateur Radio satellites.

The news feed on www.buddysplantplus.com publishes news of Amateur Radio in Space as soon as our volunteers can post it.

Please send any amateur satellite news or reports to: ans-editor [at] www.buddysplantplus.com

You can sign up for free e-mail delivery of the AMSAT News Service Bulletins via the ANS List; to join this list see: www.buddysplantplus.com

In this edition:

ISS SSTV June MHz FM
AO/FUNcube-1 Fitter Message for The Queen’s 70th Jubilee
Call for Nominations – AMSAT Board of Directors Election
JAMSAT Symposium June 25
ESA Mission Plans to De-Orbit Space Junk
June GEO Newsletter Available For Free Download
Changes to AMSAT-NA TLE Distribution for June 2
ARISS News
Upcoming Satellite Operations
Hamfests, Conventions, Maker Faires, and Other Events
Satellite Shorts From All Over

ANS AMSAT News Service Weekly Bulletins

To: All RADIO AMATEURS
From: Radio Amateur Satellite Corporation
H Street NE, Suite
Washington, DC

DATE June 05

ISS SSTV June MHz FM

Russian cosmonauts on the International Space Station (ISS) are planning to transmit Slow Scan TV (SSTV) images on MHz FM probably using the SSTV mode PD

The transmissions are part of the Moscow Aviation Institute SSTV experiment (MAI) and will be made from the amateur radio station RS0ISS in the Russian ISS Service module (Zvezda). This will be the first time the experiment will use the recently installed Kenwood DGA.

• June 8 Setup and activation GMT, stop about GMT
• June 9 start about GMT, stop about GMT

*Dates and times may be subject to change.

The signal should be receivable on a handheld with a 1/4 wave whip. If your rig has selectable FM filters try the wider filter for 25 kHz channel spacing.

You can get predictions for the ISS pass times at www.buddysplantplus.com

ARISS SSTV Blog www.buddysplantplus.com

Useful SSTV info and links www.buddysplantplus.com

[ANS thanks AMSAT-UK for the above information]

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The AMSAT President&#;s Club coins have arrived!
To commemorate the 50th anniversary of its launch on
October 15, , this year&#;s coin features
an image of AMSAT-OSCAR 6.
Join the AMSAT President&#;s Club today and help
Keep Amateur Radio in Space!
www.buddysplantplus.com
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AO/FUNcube-1 Fitter Message for The Queen’s 70th Jubilee

In June , Her Majesty The Queen becomes the first British Monarch to celebrate a Platinum Jubilee after 70 years of service.

AMSAT-UK has decided to send a special Platinum Jubilee greetings message via FUNcube-1 (AO). Anyone who receives this message and uploads it to the Data Warehouse using the Dashboard can generate a certificate to remember this historic event.

AO/FUNcube-1 is transmitting the Jubilee Fitter message on the BPSK Telemetry beacon which has a nominal frequency of MHz +/ Doppler.

The AO/FUNcube-1 Dashboard App can be downloaded from
www.buddysplantplus.com

Data Warehouse www.buddysplantplus.com

Online tracking of AO www.buddysplantplus.com?s=

[ANS thanks AMSAT-UK for the above information]

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Need new satellite antennas? Purchase Arrows, Alaskan Arrows,
and M2 LEO-Packs from the AMSAT Store. When you purchase through
AMSAT, a portion of the proceeds goes towards
Keeping Amateur Radio in Space.
www.buddysplantplus.com

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Call for Nominations – AMSAT Board of Directors Election

AMSAT solicits nominations for the AMSAT Board of Directors election, to be held in the third quarter of the year. The seats of the following three incumbent Directors expire in and will be filled by this year’s election:

Mark Hammond, N8MH
Bruce Paige, KK5DO
Paul Stoetzer, N8HM

Further, up to two Alternate Directors may be elected for one-year terms.

A valid nomination for Director must be written and requires either one Member Society or five current individual members in good standing to nominate an AMSAT member. Written nominations, with the nominee’s name, call sign, and contact information, as well as the nominators’ names, call signs, and contact information, should be sent to the Acting AMSAT Secretary:

Paul Stoetzer, N8HM
I St SW Apt V
Washington, DC USA

E-mail nominations may be sent to pstoetzer at www.buddysplantplus.com

The AMSAT bylaws require that the nomination be written and in the form specified by the Secretary. The Acting Secretary has elected to accept written nomination materials via mail or in electronic form, including e-mail or electronic image of a paper document. Fax transmissions cannot be accepted.

No matter what means are used, petitions MUST be received by the Acting Secretary no later than June 15th. The Acting Secretary will verify the qualifications of candidates and nominating members or Member Societies as petitions are received, and will notify candidates whether their nominations are in order by the end of June.

[ANS thanks Paul Stoetzer, N8HM, AMSAT Executive Vice President and Acting Secretary for the above information]

JAMSAT Symposium June 25

The AMSAT organization of Japan, JAMSAT, will hold its annual Symposium on Saturday, June 25 from ~ JST (UTC +9 hours). Anyone can participate.

Registration starts at JST ( UTC or EDT).
Venue: Held on Zoom
If you would like to participate, please contact by e-mail (ja3nas [at mark] www.buddysplantplus.com) to be informed of the opening URL. Please include the following in your email:
・E-mail address
・Name
・Call sign
* For conventional web meeting participants, we have already provided information on the holding URL.
* Those who have already been informed of the holding URL do not need to apply.

In addition, a social gathering is scheduled from ~ JST. Please join us. Please prepare your own drinks. (A toast will be made at the opening)

In addition, JS1YAQ is scheduled to be operated during this time. It is a station with a particularly high point. It is also related to the points of the award, so please join us.

The JAMSAT Symposium Program may be found at www.buddysplantplus.com

[ANS thanks JAMSAT for the above information]

ESA Mission Plans to De-Orbit Space Junk

The world’s first mission to remove several small telecommunications satellites from orbit once they reach the end of their operational service is about to start building and testing its prototype spacecraft.

British-based in-orbit servicing company Astroscale – working in an ESA Partnership Project with satellite operator OneWeb – will begin manufacturing the first commercial “servicer” prototype designed to capture multiple satellites in low Earth orbit under the ESA Sunrise Programme.

Companies such as OneWeb are launching constellations comprised of hundreds of communications satellites to connect people in the hardest-to-reach locations through global satellite internet broadband services.

OneWeb currently has satellites orbiting approximately km above the Earth; its completed constellation will number almost satellites.

Removing these telecommunications satellites from their orbits once they are at the end of their lives is essential to ensure that today’s interconnected digital world is not compromised by collisions that damage active satellites in space – and to protect the low Earth orbit environment as a natural and shared resource.

There are currently two options for removing end-of-life OneWeb satellites from their orbits at the end of their predicted five to six years of service.

Each has been allocated enough fuel to be able to actively deorbit at the end of its useful lifetime. But, in case of failure, each has also been built with either a magnetic or a grappling fixture, so that a servicer spacecraft could collect and actively deorbit the satellite.

The servicer spacecraft that Astroscale will build and test is called “ELSA-M” and is planned for launch in The servicer spacecraft will be the first “space sweeper” capable of removing multiple defunct satellites from their orbits in a single mission.

Following this demonstration, Astroscale will offer a commercial service for clients that operate satellite constellations in low Earth orbit, providing the technology and capability to make in-orbit servicing part of routine satellite operations by

ESA fosters innovation in the European space industry through its Partnership Projects, which seek to de-risk the investments of its industrial partners to meet market needs.

UK Science Minister George Freeman said: “With thousands of satellites already in orbit and thousands more being launched every year, addressing the issue of space debris and finding new ways to remove defunct spacecraft and other types of space junk is of ever-increasing importance – to both reduce the cost of debris damage for satellite operators and ensure space is safe and sustainable.

“That is why the UK government has made space sustainability a key theme of our National Space Strategy and it is fantastic to see leading roles for UK companies Astroscale and OneWeb in this ESA project, helping us continue to show UK technology leadership in this important area.”

Paul Bate, Chief Executive of the UK Space Agency, said: “Space debris threatens the satellites we depend on every day for vital services, such as navigation, banking and communications.

“That’s why the UK is taking action, by funding new commercial technologies to remove debris from space and working with international partners to lead efforts to promote sustainability. This latest phase of the Sunrise programme partnership between Astroscale and OneWeb will deliver an innovative spacecraft servicer to remove multiple defunct satellites, putting the UK at the forefront of efforts to clear up space.”

Massimiliano Ladovaz, Chief Technology Officer at OneWeb, said: “Responsible space is central to our mission at OneWeb and we are committed to sustainable practices in all the environments in which we operate. The development of the ELSA-M servicer prototype is another significant milestone towards a responsible approach to space, ensuring that our satellites can be de-orbited and that the low Earth orbit environment is protected as a natural and shared resource.”

John Auburn, Managing Director of Astroscale, said: “Phase 3 of the Sunrise programme is a major step forward for ELSA-M towards an in-orbit demonstration and the start of a commercial debris removal service, capable of removing multiple defunct satellites in a single mission. The ELSA-M in-orbit demonstration, planned for late , will build on lessons learned from the ELSA-d mission and demonstrate our innovative rendezvous, capture and de-orbit capabilities with a full-size constellation client.”

Elodie Viau, Director of Telecommunications and Integrated Applications at ESA, said: “It is vital to ensure the responsible use of space to protect today’s interconnected world, because our digital economy and society rely on the ability to communicate. I am proud of ESA’s track record in fostering innovation in the space industry in Europe, bringing to fruition new ways of ensuring the sustainable use of space, and of the role that ESA’s Partnership Projects play as a trusted partner for investors, operators and industry.”

The ESA Sunrise programme is supported by the UK Space Agency and involves not only OneWeb and Astroscale, but also British start-up companies SatixFy and Celestia UK, as well as the University of Surrey.

[ANS thanks the European Space Agency (ESA) for the above information]

June GEO Newsletter Available For Free Download

The June PDF of the GEO Newsletter weather satellite publication produced by the Group for Earth Observation is now available for free download

The Group for Earth Observation&#;s aim is to enable amateur reception of weather and earth imaging satellites that are in orbit or planned for launch in the near future.

Membership of GEO is free.

This edition includes:
• Floodwaters Reach Australia’s Channel Country
• Record Low for Great Salt Lake
• Ice Shelf Collapse in East Antarctica
• Currently Active Weather Satellites and Frequencies

Download the GEO Newsletter from
www.buddysplantplus.com

Previous newsletters are at
www.buddysplantplus.com

Group for Earth Observation
www.buddysplantplus.com
www.buddysplantplus.com

[ANS thanks Southgate ARC for the above information]

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Want to fly the colors on your own grid expedition?
Get your AMSAT car flag and other neat stuff
from our Zazzle store!
25% of the purchase price of each product goes
towards Keeping Amateur Radio in Space
www.buddysplantplus.com

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Changes to AMSAT-NA TLE Distribution for June 2

Two Line Elements or TLEs, often referred to as Keplerian elements or keps in the amateur community, are the inputs to the SGP4 standard mathematical model of spacecraft orbits used by most amateur tracking programs. Weekly updates are completely adequate for most amateur satellites. TLE bulletin files are updated Thursday evenings around UTC, or more frequently if new high interest satellites are launched. More information may be found at www.buddysplantplus.com

The following satellite has been added to this week&#;s AMSAT-NA TLE distribution:

Foresail-1 &#; NORAD Cat ID (Thanks to Nico Janssen, PA0DLO for the identification).

[ANS thanks Ray Hoad, WA5QGD, AMSAT Orbital Elements Manager, for the above information]

ARISS NEWS

Amateurs and others around the world may listen in on contacts between amateurs operating in schools and allowing students to interact with astronauts and cosmonauts aboard the International Space Station. The downlink frequency on which to listen is MHz worldwide, unless otherwise noted.

Completed contacts:

Moscow Autonomous Educational Institution &#;Lyceum &#; Engineering Center&#;, Kazan, Russia, direct via R4UAB. The ISS callsign is presently scheduled to be RSØISS. The scheduled crewmember is Sergey Korsakov. Contact was successful at Thu UTC. Congratulations to the &#;Lyceum &#; Engineering Center&#; students and Sergey!

Istituto Comprensivo “Losapio–S.F. Neri”, Gioia del Colle, Puglia, Italy, direct via IZ7RTN. The ISS callsign is presently scheduled to be IRØISS. The scheduled crewmember is Samantha Cristoforetti, IZØUDF. Contact was scheduled for: Sat UTC 64 deg

Matinecock District, Suffolk County NY Boy Scouts, Medford, NY, telebridge via AB1OC. The ISS callsign is presently scheduled to be NA1SS. The scheduled crewmember is Kjell Lindgren, KO5MOS. Contact was scheduled for: Sat UTC 53 deg

Upcoming contacts:

Scuola media www.buddysplantplus.com, Nuoro, Sardegna, Italy, direct via IKØWGF. The ISS callsign is presently scheduled to be IRØISS. The downlink frequency is presently scheduled to be MHz. The scheduled crewmember is Samantha Cristoforetti, IZØUDF. Contact is go for: Mon UTC 40 deg. Watch for Livestream at: www.buddysplantplus.com

Bauman Moscow State Technical University, Moscow, Russia, direct via RM3A. The ISS callsign is presently scheduled to be RSØISS. The scheduled crewmember is Denis Matveev. Contact is go for Mon UTC.

The latest information on the operation mode can be found at www.buddysplantplus.com

The latest list of frequencies in use can be found at www.buddysplantplus.com

[ANS thanks Charlie Sufana, AJ9N, one of the ARISS operation team mentors for the above information]

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AMSAT, along with our ARISS partners, is developing an Amateur
Radio package, including two-way communication capability, to
be carried on-board Gateway in lunar orbit.

Support AMSAT&#;s projects today at www.buddysplantplus.com

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Upcoming Satellite Operations

WL7T: EL84, June

KJ7DZ: CN74 rove trip on June Hope for good weather. Will log all contacts with KJ7DZ/R.

K4DCA: plans to be in CN74 on June , too. Hopefully we can raise the number on the heat map.

Wl7T: I locked EL58 in for June 29, 30, and July 1. I plan to work 6 meters for the majority of the time with sat passes as requested. I am going to operate from a boat from around ~9 AM – 5 PM each day.

W3IPA: DM42 vacation planned for Jul Aug 6th will be on FM passes vacation style. I will be close to DM41 so might be able to work a gridline. Will post more updates closer to that week!

N8MR: EN 57,67,56 8/6 through 8/ More to come as date gets closer.

AD0HJ Eastern Iowa Rove: Time for Mitch to activate several new satellite grid squares and green up some more #GridMaster maps. Next trip is planned for grids EN30/31/32/33/40/41/42/43 between June 2nd and June 5th. More information soon

KX9X & N9NCY Wild West Rove: Sean and Nancy will be on the road from July while hiking in National Parks. They will travel through twelve states and over 50 grids, planning activation on FM and linear satellites. Extensive operation in Montana and North Dakota along the northern border (all the “8” grids). There will also be 6 meter and occasional HF POTA activity as well. Complete info on their trip can be found on their website www.buddysplantplus.com

[ANS thanks Paul Overn, KE0PBR, AMSAT rover page manager, for the above information]

Hamfests, Conventions, Maker Faires, and Other Events

AMSAT Ambassadors provide presentations, demonstrate communicating through amateur satellites, and host information tables at club meetings, hamfests, conventions, maker faires, and other events.

Upcoming “How to Work the “Easy” Satellites” talks are scheduled …
Puget Sound Repeater Group – this weekend
Orange County ARA CA – May 20
Cal Poly Pomona – TBD
WARA – Orange County CA – June 11
And it “feels” like lives are improving here in So California, as that meeting for WARA in June will be (hopefully) an IN-PERSON show! (Have to tune up my projector and dust off the DaLite projection screen!)
Think a minute lively, informative, and fun “How to Work the Easy Satellites” Zoom presentation would be appropriate for your convention or club? Always included are overviews of the ARRL, AMSAT, and ARISS. And pre-presentation questions are solicited and welcome. Send an email or call!
Clint Bradford, K6LCS.

Rocky Mountain ARRL Division Convention
Friday, October 7th, to Sunday, October 9th,
Event Center at Archer
Archer Pkwy
Cheyenne, Wyoming
www.buddysplantplus.com

[ANS thanks Paul Overn, KE0PBR, AMSAT Events page manager, for the above information]

Satellite Shorts From All Over

+ A QO user meeting is being planned during the HAM RADIO event in Friedrichshafen, Germany. The meeting will take place on Saturday, June 25, starting at 7 p.m. CEST at a restaurant about a 12 minute walk or 5 minute drive from the event site. Participants are asked to register with callsign and name at: www.buddysplantplus.com (ANS thanks AMSTA-DL for the above information)

+ NASA awarded contracts to Axiom Space and Collins Aerospace to provide spacesuits for International Space Station spacewalks and Artemis moonwalks. NASA announced June 1 it selected the two companies for Exploration Extravehicular Activity Services, or xEVAS, contracts to support the development of new spacesuits as well as purchasing spacesuit services. The companies will own the suits they develop and will effectively rent them to NASA for space station and Artemis missions, while also being able to offer the suits to other customers. (ANS thanks www.buddysplantplus.com for the above information)

+ NASA&#;s Mars Atmosphere and Volatile EvolutioN, or MAVEN, mission returned to normal science and relay operations on May 28, , after recovering from an extended safe mode event. The spacecraft encountered problems in February with its Inertial Measurement Units (IMUs). The mission team successfully diagnosed the issue with these navigation instruments and developed a system for the spacecraft to navigate by the stars, which should allow for continued MAVEN mission operations through the next decade. MAVEN launched in November and entered orbit around Mars in September The mission&#;s goal is to explore the planet&#;s upper atmosphere, ionosphere, and interactions with the Sun and solar wind to explore the loss of the Martian atmosphere to space. (ANS thanks www.buddysplantplus.com for the above information)

+ Platinum Jubilee special event station GB70U is active on the amateur radio QO geostationary satellite transponders. (ANS thanks Southgate ARC for the above information)

+ Spain&#;s amateur satellite organisation AMSAT-EA has released the English language PDF version of their newsletter for May for free download in PDF at: www.buddysplantplus.com
(ANS thanks Southgate ARC for the above information)

+ The NEXUS (FO) operation schedule for June may be found at www.buddysplantplus.com?p= FO is in eclipse until late July and will generally not be available until that time. (ANS thanks JAMSAT for the above information)

+ Amateur radio, and portable operating in particular, will receive some high-profile coverage on national television in the UK on Sunday, June 5. Countryfile, the long-running BBC One program that reports on rural, agricultural, and environmental issues in the United Kingdom, will air at 6 p.m. BST ( UTC) on the main BBC One channel. This episode will be based out of the Welsh island of Flat Holm in the Bristol Channel, which was the site of Guglielmo Marconi&#;s first radio transmissions overseas. Countryfile presenters Ellie Harrison and Matt Baker will join Summits on the Air (SOTA) operator Ben Lloyd, GW4BML, as he sets up a portable station on the island to contact SOTA activators on summits around the United Kingdom. (ANS thanks Southgate ARC for the above information)

Join AMSAT today at www.buddysplantplus.com

In addition to regular membership, AMSAT offers membership to:

* Societies (a recognized group, clubs or organization).
* Primary and secondary school students are eligible for membership at one-half the standard yearly rate.
* Post-secondary school students enrolled in at least half time status shall be eligible for the student rate for a maximum of 6 post-secondary years in this status.
* Memberships are available for annual and lifetime terms.

Contact info [at] www.buddysplantplus.com for additional membership information.

73 and remember to help Keep Amateur Radio in Space!

This week&#;s ANS Editor, Mark Johns, K0JM
k0jm at amsat dot org

Categories AMSAT News Service

Thrombolytic Therapy

Continuing Education Activity

Thrombolytics or fibrinolytics are a group of medications used in the management and treatment of dissolving intravascular clots. They are in the plasminogen activator class of drugs. This activity describes the indications, action, and contraindications for thrombolytics. This activity will highlight the mechanism of action and adverse event profile pertinent for members of the interprofessional team in the treatment of patients with intravascular clots such as Acute myocardial infarction, acute ischemic stroke, and related conditions.

Objectives:

Identify the mechanism of action of thrombolytics.
Describe the potential adverse effects associated with various thrombolytic agents.
Review the monitoring for patients on thrombolytic therapy.
Summarize interprofessional team strategies for improving care coordination and communication to advance thrombolytics and improve outcomes.

Access free multiple choice questions on this topic.

Indications

Thrombolytic treatment is also known as fibrinolytic or thrombolysis to dissolve dangerous intravascular clots to prevent ischemic damage by improving blood flow. Thrombosis is a significant physiological response that limits hemorrhage caused by large or tiny vascular injury. The physiological hemostatic response is well-controlled by intrinsic antithrombotic properties and fibrinolysis. Thrombus formation is supposed to be confined to localized areas of tissue injury. Any intravascular thrombus without damage that impedes the blood flow is considered abnormal. Any form of inherited or acquired hypercoagulable state may give rise to intravascular thrombus formation. Upon formation, an abnormal thrombus may propagate until complete blockage of the arterial lumen or may detach and travel to block downstream vascular lumen. Thromboembolism has the following clinical outcomes where a thrombolytic therapy can be used.

Acute myocardial infarction (AMI)
Deep vein thrombosis (DVT)
Pulmonary embolism (PE)
Acute ischemic stroke (AIS)
Acute peripheral arterial occlusion
Occlusion of indwelling catheters
Intracardiac thrombus formation.

There are two ways thrombolytic agents can be given: systemic administration through a peripheral IV or local release by a catheter after navigating to the site of the clot. Thrombolytic or fibrinolytic agents are often referred to as plasminogen activators. All of the available thrombolytic agents are serine proteases that cleave plasminogen into active plasmin. Currently, available thrombolytic agents include the following:

Streptokinase
Alteplase
Reteplase
Tenecteplase
Urokinase
Prourokinase
Anistreplase(APSAC)

Streptokinase

Due to its relatively low cost with reasonable efficacy and safety, it is the most widely used fibrinolytic agent worldwide. While it has lower efficacy than alteplase, the risk of intracranial hemorrhage is less. Re-administration of streptokinase within six months is not considered safe due to its high antigenicity and associated high antistreptococcal antibody titer. It is not a plasminogen activator. However, after binding with free circulating plasminogen, it forms a complex that converts additional plasminogen to active plasmin. As it is produced from streptococcus, it often exerts febrile reactions and other allergic reactions. Dose dependant hypotension is another potential caution for this drug.[1]

Alteplase

Alteplase is the recombinant plasminogen activator and identical to native tPA, which is more fibrinspecific with a plasma halflife of 46 minutes. It is the most often used fibrinolytic in the treatment of acute cardiovascular events (STEMI), pulmonary embolism(PE), and acute ischemic stroke(AIS). Theoretically, alteplase should only be active on the surface of a fibrin clot. However, in reality, it exhibits systemic fibrinolysis; thus, a substantial amount of circulating fibrin degradation products has been observed with a moderate risk of bleeding. Alteplase is not antigenic and, therefore, seldom associated with any allergic manifestations.[2][3]

Tenecteplase (TNK-tPA)

It is a commonly used fibrinolytic agent across the USA (except for ischemic stroke), Canada, and many European countries. It is as efficient as alteplase while exerting a lower risk of non-cerebral bleeding. Tenecteplase has higher fibrin specificity and a longer plasma half-life with final clearance, mostly through hepatic metabolism. Furthermore, it lacks antigenicity and more comfortable to administer.[4]

Reteplase

It is a second generation recombinant plasminogen activator that works more rapidly with lower bleeding tendency than the first generation agent alteplase. It demonstrates weaker binding with fibrin than native tPA does, allows more free diffusion through the clot rather than binding only to the surface as tPA does. Additionally, reteplase does not show competitive inhibition of plasminogen, therefore allows plasminogen to transform into clot dissolving plasmin. These characteristics, in sum, explain its faster clot resolution than other agents. The FDA approved reteplase administration of two boluses of 10U 30 minutes apart for AMI management. Each of these boluses is administered over 2 minutes. Like alteplase, reteplase can be readministered when necessary and is not antigenic.[5]

Urokinase

Urokinase has been used most often for occluded catheters and peripheral vascular thrombus. It is considered a physiologic thrombolytic that usually produced by renal parenchyma, thus purified from human urine. However, recombinant urokinase is also commercially available. In contrast to streptokinase, urokinase directly cleaves plasminogen into plasmin. Its low antigenicity allows repeated dosing without antigenic problems.[6]

Prourokinase

Prourokinase is a relatively inactive precursor that necessitates the conversion to urokinase to become active. The need for such conversion provides the fibrin-specific physiologic properties of pro-urokinase. It is a newer agent that already in clinical trials.[7]

Anistreplase

Anisoylated purified streptokinase activator complex (APSAC), or anistreplase, is a complex mixture of streptokinase and plasminogen that does not depend on circulating plasminogen to be effective. Despite its many theoretical benefits over streptokinase, it exerts high antigenicity. Similar to streptokinase, anistreplase does not distinguish between circulating vs. fibrin-bound plasminogen; subsequently, it produces the systemic lytic state.

Mechanism of Action

Hemostasis and thrombosis result from an integrated and interactive response of the coagulation factors, blood vessels, and platelets. During thrombosis, circulating prothrombin is converted to its active form thrombin by activated platelets. Active thrombin then converts the fibrinogen into fibrin with the eventual formation of a fibrin matrix. This process is counterbalanced by plasmin derived from plasminogen, which gathers in the fibrin matrix. Tissue plasminogen activator (tPA) is a natural fibrinolytic found in endothelial cells. It shows fibrin specificity and affinity. The end goal of this therapy is to convert plasminogen into plasmin which is accomplished at the location of the thrombus and on the surface of fibrin by the binding of tPA to plasminogen. This binding helps the conversion.

They can be subdivided into two categories which are as follows:

Fibrin-specific agents: These agents mostly need the presence of fibrin for the conversion, but on a minimal scale can do so in the absence of fibrin too. e.g. alteplase (tPA), reteplase (recombinant plasminogen activator [r-PA]), and tenecteplase
Non-fibrin-specific agents: These do not need fibrin presence for conversion, which is why they can do this systemically. e.g., streptokinase

Streptokinase is the first historical thrombolytic agent extracted from certain streptococcal strains. Researchers found another potential fibrinolytic agent in human urine named urokinase. In contrast to streptokinase, urokinase lacks antigenicity and directly converts plasminogen to plasmin. These two substances catalyze plasmin formation from plasminogen and are affected slightly by the local fibrin clot, thus having a higher systemic effect. Streptokinase and urokinase are not used widely in the United States but are used elsewhere because of their lower cost.[8]

Administration

Acute Ischemic Stroke

Fibrinolytic therapy in acute ischemic stroke is used to break up blood clots preventing blood flow to the brain with the hope of restoring blood flow to the areas of the brain that have not yet suffered infarct. Intravenous alteplase (tPA) is the mainstay of thrombolysis in acute ischemic stroke that improves functional outcome significantly when administered within hours of stroke onset. All patients with acute ischemic stroke who present within a hour window from their last known well time and without any absolute contraindication should receive treatment with intravenous alteplase (tPA). Mechanical thrombectomy is beneficial when an acute ischemic stroke results from a proximal intracranial arterial occlusion.[3]

Acute Myocardial Infarction

Fibrinolytic therapy remains vital as a treatment for ST-elevation myocardial infarctions in many places where acute percutaneous coronary intervention is not an option and during transport to hospitals with this facility. Fibrinolytic therapy is a proven therapy in the treatment of AMI. It is widely available and can be administered by qualified health care professionals even in the prehospital setting. The greater the time necessary to deliver the therapy after the AMI lessens its efficacy. A useful means to quantify the time window is the "door to needle time," which should be kept under 30 minutes to get the maximum results.[9][10]

Acute Limb Ischemia

Primary fibrinolysis is the treatment of choice for non&#x;life-threatening limb ischemia from in-situ thrombosis of fewer than 14 days of duration. Local fibrinolysis usually takes 6 to 72 hours to achieve clot lysis; therefore, it is not suitable for patients with limb-threatening ischemia.[11][12]Pulmonary Embolism (PE)

The FDA approved the following thrombolytic agents for use in acute PE: alteplase, urokinase, and streptokinase. Tenecteplase is currently under study but not yet recommended. Clinicians should avoid simultaneous administration of unfractionated heparin (UFH) in acute massive PE, and it should only be started for prophylaxis of recurrent thrombosis following fibrinolytic therapy has been given and when the activated partial thromboplastin time (aPTT) has come down to a value lower than two times the normal value.

Deep Vein Thrombosis

Anticoagulation is the mainstay of initial treatment for DVT. However, certain patients with extensive acute DVT with a low risk of bleeding can undergo catheterdirected thrombolysis to lyse the intravenous clot. Patient criteria include symptoms of less than 14 days (acute DVT),upper-extremity DVT or proximal DVT, and good functional status.[13][14]

Combination therapy with different fibrinolytic agents and glycoprotein inhibitors is not generally recommended due to the increased risk of bleeding and lack of any mortality benefit.

Adverse Effects

Adverse effects of any fibrinolytic agents are almost similar, which include, but are not limited to, bleeding, hypotension, allergic reactions, angioedema, and reperfusion arrhythmias (when used in acute MI). Among all fibrinolytic agents, streptokinase is the most antigenic; thus, it is most frequently complicated by allergic reactions and hypotension.

Bleeding is the most frequent complication of thrombolytic therapy and can occur in puncture sites or spontaneously anywhere inside the body. Intracranial hemorrhage or hemorrhagic stroke is the greatest concern. Risk factors associated with hemorrhagic complications include elderly patients, uncontrolled hypertension, recent stroke or surgery, presence of bleeding diathesis, and concurrent use of anticoagulants.[15][16] Overdose most often occurs when administered in a non-body-weight adjusted manner and can cause severe hemorrhagic complications.

Contraindications

Absolute Contraindications for Thrombolytic Treatment

Recent intracranial hemorrhage (ICH)
Structural cerebral vascular lesion
Intracranial neoplasm
Ischemic stroke within three months
Possible aortic dissection
Active bleeding or bleeding diathesis (excluding menses)
Significant head injury or facial trauma within three months
Recent Intracranial or spinal surgery
Severe uncontrolled hypertension
For streptokinase, previous treatment within six months[17]

Relative Contraindications for Thrombolytic Treatment

History of severe and poorly controlled hypertension
Severe hypertension at presentation (systolic blood pressure mmHg or diastolic blood pressure mmHg)
Prolonged (10 minutes) cardiopulmonary resuscitation (CPR) or major surgery within three weeks.
History of ischemic stroke.
Dementia
Internal bleeding within 2 to 4 weeks
Noncompressible vascular punctures
Pregnancy
Active peptic ulcer
Current therapy of anticoagulant associated with an elevated international normalized ratio (INR) higher than or a prothrombin time (PT) longer than 15 seconds[17]

Monitoring

Patients receiving thrombolytic therapy must undergo a constant neurologic and cardiovascular evaluation with blood pressure monitoring every 15 minutes during and after tPA infusion for at least 2 hours, then half-hourly for 6 hours and hourly for the next 16 hours after injection. Strict BP monitoring is essential to prevent complications. Thrombolytic therapy should be stopped urgently with any signs of neurologic deterioration, and the patient should receive an emergency computed tomography (CT).

Fibrinolytic agents or any anticoagulants must be stopped immediately with any evidence of bleeding complications in a patient with ongoing fibrinolytic therapy. In the next step, supportive measures should be instituted, including volume correction and blood factor transfusion.

If the patient also has been on concomitant heparin, protamine sulfate can reverse the heparin effect.[18]

Toxicity

Fresh frozen plasma (FFP) cryoprecipitate can help refurbish clotting factors and fibrin, depending upon availability and patient comorbidities. For the fibrinolytic agents' reversal of action, aminocaproic acid is useful because of its specific action. Aminocaproic acid should not be introduced unless life-threatening hemorrhage as it inhibits intrinsic physiologic fibrinolytic activity, which in turn may precipitate widespread thrombosis with potential end-organ damage at many sites. The drug may worsen disseminated intravascular coagulation (DIC) and heparin-induced thrombocytopenia.[19]

Enhancing Healthcare Team Outcomes

Pre-hospital thrombolytic therapy is a new treatment paradigm that can dramatically change patient outcomes. Several studies have shown that trained pre-hospital professionals may identify ST-segment elevation with 12 lead ECGs, thereby playing a role in pre-hospital administration of thrombolytic or advance notification to the coronary care facility. However, pre-hospital fibrinolysis is safe and reasonable when administered by skilled and first responders. Tissue plasminogen activator, alteplase, or modified forms of it reteplase or tenecteplase are commonly used fibrinolytic agents in pre-hospital settings. Reteplase or tenecteplase is preferable for their convenient single or doublebolus dosing. Besides, to ensure standard out of hospital thrombolytic treatment, appropriate protocols with checklists, interpretation, and transmission of 12 lead ECG, advanced cardiac life support (ACLS) training, and uninterrupted availability of medical direction is mandatory.

When fibrinolytic is used in acute ischemic stroke, strict blood pressure monitoring and control are essential to prevent hemorrhagic complications with goal blood pressure less than / mmHg. Adjunctive therapies with anticoagulants and antiplatelet should be avoided within 24 hours of thrombolytic treatment for acute ischemic stroke. An emergent CT scan of the brain is necessary if there is a change in neurologic examination during or after thrombolytic administration in the setting of acute ischemic stroke.

Thrombolytic therapy is a crucial tool in treating conditions where it is indicated (e.g., AMI, occlusive stroke). It requires the coordinated efforts of an entire interprofessional team, including EMTs/paramedics, clinicians, specialists, mid-level practitioners, nurses, and pharmacists. Through collaborative effort and open communication between all these disciplines, patients who require thrombolytic therapy can achieve the best possible outcomes with the fewest adverse events. [Level 5]

References

1.: Edwards Z, Nagalli S. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Nov 25, Streptokinase. [PubMed: ]
2.: Reed M, Kerndt CC, Nicolas D. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): May 9, Alteplase. [PubMed: ]
3.: Dillon GM, Stevens S, Dusenbury WL, Massaro L, Toy F, Purdon B. Choosing the Correct "-ase" in Acute Ischemic Stroke: Alteplase, Tenecteplase, and Reteplase. Adv Emerg Nurs J. Jul/Sep;41(3) [PubMed: ]
4.: Zitek T, Ataya R, Brea I. Using Tenecteplase for Acute Ischemic Stroke: What Is the Hold Up? West J Emerg Med. Feb 24;21(2) [PMC free article: PMC] [PubMed: ]
5.: Mohammadi E, Mahnam K, Jahanian-Najafabadi A, Sadeghi HMM. Design and production of new chimeric reteplase with enhanced fibrin affinity: a theoretical and experimental study. J Biomol Struct Dyn. Mar;39(4) [PubMed: ]
6.: Cao W, Ni X, Wang Q, Li J, Li Y, Chen T, Wang X. Early diagnosis and precision treatment of right ovarian vein and inferior vena cava thrombosis following caesarean section: A case report. Exp Ther Med. Apr;19(4) [PMC free article: PMC] [PubMed: ]
7.: Gurewich V, Pannell R, Simmons-Byrd A, Sarmientos P, Liu JN, Badylak SF. Thrombolysis vs. bleeding from hemostatic sites by a prourokinase mutant compared with tissue plasminogen activator. J Thromb Haemost. Jul;4(7) [PubMed: ]
8.: Chapin JC, Hajjar KA. Fibrinolysis and the control of blood coagulation. Blood Rev. Jan;29(1) [PMC free article: PMC] [PubMed: ]
9.: Wang J, Toan S, Zhou H. Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: New insights into the mechanisms and therapeutic potentials. Pharmacol Res. Jun; [PubMed: ]
: Bendary A, Tawfik W, Mahrous M, Salem M. Fibrinolytic therapy in patients with ST-segment elevation myocardial infarction: Accelerated versus standard Streptokinase infusion regimen. J Cardiovasc Thorac Res. ;9(4) [PMC free article: PMC] [PubMed: ]
: Olinic DM, Stanek A, T&#x;taru DA, Homorodean C, Olinic M. Acute Limb Ischemia: An Update on Diagnosis and Management. J Clin Med. Aug 14;8(8) [PMC free article: PMC] [PubMed: ]
: Theodoridis PG, Davos CH, Dodos I, Iatrou N, Potouridis A, Pappas GM, Staramos D, Antoniadis P, Argitis V, Dervisis K. Thrombolysis in Acute Lower Limb Ischemia: Review of the Current Literature. Ann Vasc Surg. Oct; [PubMed: ]
: Fleck D, Albadawi H, Shamoun F, Knuttinen G, Naidu S, Oklu R. Catheter-directed thrombolysis of deep vein thrombosis: literature review and practice considerations. Cardiovasc Diagn Ther. Dec;7(Suppl 3):SS [PMC free article: PMC] [PubMed: ]
: Vedantham S, Piazza G, Sista AK, Goldenberg NA. Guidance for the use of thrombolytic therapy for the treatment of venous thromboembolism. J Thromb Thrombolysis. Jan;41(1) [PMC free article: PMC] [PubMed: ]
: Nazari J, Davison R, Kaplan K, Fintel D. Adverse reactions to thrombolytic agents. Implications for coronary reperfusion following myocardial infarction. Med Toxicol Adverse Drug Exp. Jul-Aug;2(4) [PubMed: ]
: Karthikeyan G, Mathew N, Math RS, Devasenapathy N, Kothari SS, Bahl VK. Timing of adverse events during fibrinolytic therapy with streptokinase for left-sided prosthetic valve thrombosis. J Thromb Thrombolysis. Aug;32(2) [PubMed: ]
: Fugate JE, Rabinstein AA. Absolute and Relative Contraindications to IV rt-PA for Acute Ischemic Stroke. Neurohospitalist. Jul;5(3) [PMC free article: PMC] [PubMed: ]
: Kaufman C, Kinney T, Quencer K. Practice Trends of Fibrinogen Monitoring in Thrombolysis. J Clin Med. May 10;7(5) [PMC free article: PMC] [PubMed: ]
: Kaseer H, Sanghavi D. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Mar 15, Aminocaproic Acid. [PubMed: ]
: Kabrhel C, Rosovsky R, Channick R, Jaff MR, Weinberg I, Sundt T, Dudzinski DM, Rodriguez-Lopez J, Parry BA, Harshbarger S, Chang Y, Rosenfield K. A Multidisciplinary Pulmonary Embolism Response Team: Initial Month Experience With a Novel Approach to Delivery of Care to Patients With Submassive and Massive Pulmonary Embolism. Chest. Aug;(2) [PubMed: ]
: Rosovsky R, Zhao K, Sista A, Rivera-Lebron B, Kabrhel C. Pulmonary embolism response teams: Purpose, evidence for efficacy, and future research directions. Res Pract Thromb Haemost. Jul;3(3) [PMC free article: PMC] [PubMed: ]

The news feed on www.buddysplantplus.com publishes news of Amateur Radio in Space as soon as our volunteers can post it.

Please send any amateur satellite news or reports to: ans-editor [at] www.buddysplantplus.com

You can sign up for free e-mail delivery of the AMSAT News Service Bulletins via the ANS List; to join this list see: www.buddysplantplus.com

In this edition:

ISS SSTV June MHz FM
AO/FUNcube-1 Fitter Message for The Queen’s 70th Jubilee
Call for Nominations – AMSAT Board of Directors Election
JAMSAT Symposium June 25
ESA Mission Plans to De-Orbit Space Junk
June GEO Newsletter Available For Free Download
Changes to AMSAT-NA TLE Distribution for June 2
ARISS News
Upcoming Satellite Operations
Hamfests, Conventions, Maker Faires, June 5, and Other Events
Satellite Shorts From All Over

ANS AMSAT News Service Weekly Bulletins

To: All RADIO AMATEURS
From: Radio Amateur Satellite Corporation
H Street NE, Suite
Washington, DC

DATE June 05

ISS SSTV June MHz FM

Russian cosmonauts on the International Space Station (ISS) are planning to transmit Slow Scan TV (SSTV) images on MHz FM probably using the SSTV mode PD

The transmissions are part of the Moscow Aviation Institute SSTV experiment (MAI) and will be made from the amateur June 5 station RS0ISS in the Russian ISS Service module (Zvezda). This will be the first time the experiment will use the recently installed Kenwood DGA.

• June 8 Setup and activation GMT, stop about GMT
• June 9 start about GMT, stop about GMT

*Dates and times may be subject to change.

The signal should be receivable on a handheld with a 1/4 wave whip. If your rig has selectable FM filters try the wider filter for 25 kHz channel spacing.

You can get predictions for the ISS pass times at www.buddysplantplus.com

ARISS SSTV Blog www.buddysplantplus.com

Useful SSTV June 5 and links www.buddysplantplus.com

[ANS thanks AMSAT-UK for the above information]

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The AMSAT President&#;s Club coins have arrived!
To commemorate the 50th anniversary of its launch on
October 15,this year&#;s coin features
an image of AMSAT-OSCAR 6.
Join the AMSAT President&#;s Club today and help
Keep Amateur Radio in Space!
www.buddysplantplus.com
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AO/FUNcube-1 Fitter Message for The Queen’s 70th Jubilee

In JuneHer Majesty The Queen becomes the first British Monarch to celebrate a Platinum Jubilee after 70 years of service.

AO/FUNcube-1 is transmitting the Jubilee Fitter message on the BPSK Telemetry beacon which has a nominal frequency of MHz +/ Doppler.

The AO/FUNcube-1 Dashboard App can be downloaded from
www.buddysplantplus.com

Data Warehouse www.buddysplantplus.com

Online tracking of AO www.buddysplantplus.com?s=

[ANS thanks AMSAT-UK for the above information]

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Call for Nominations – AMSAT Board of Directors Election

AMSAT solicits nominations for the AMSAT Board of Directors election, to be held in the third quarter of the year. The seats of the following 2021Free Activators incumbent Directors expire in and will be filled by this year’s election:

Mark Hammond, N8MH
Bruce Paige, KK5DO
Paul Stoetzer, N8HM

Further, up to two Alternate Directors may be elected for one-year terms.

A valid nomination for Director must be written and requires either one Member Society or five current individual members in good standing to nominate an AMSAT member, 2021Free Activators. Written nominations, with the nominee’s name, call sign, 2021Free Activators, and contact information, as well as the nominators’ names, call signs, and contact information, should be sent to the Acting AMSAT Secretary:

Paul Stoetzer, N8HM
I St SW Apt V
Washington, DC USA

E-mail nominations may be sent to pstoetzer at www.buddysplantplus.com

[ANS thanks Paul Stoetzer, N8HM, AMSAT Executive Vice President and Acting Secretary for the above information]

JAMSAT Symposium June 25

The AMSAT organization of Japan, JAMSAT, will hold its annual Symposium on Saturday, June 25 from ~ JST (UTC +9 hours). Anyone can participate.

Registration starts at JST ( UTC or EDT).
Venue: Held on Zoom
If you would like to participate, please contact by e-mail (ja3nas [at mark] www.buddysplantplus.com) to be informed of the opening URL. Please include the following in your email:
・E-mail address
・Name
・Call sign
* For June 5 web meeting participants, 2021Free Activators have already provided information on the holding URL.
* Those who have already been informed of the holding URL do not need to apply.

In 2021Free Activators, a social gathering is scheduled from ~ JST. Please join us. Please prepare your own drinks. (A toast will be made at the opening)

In addition, JS1YAQ is scheduled to be operated during this time. It is a station with a particularly high point. It is also related to the points of the award, June 5, so please join us.

The JAMSAT Symposium Program may be found at www.buddysplantplus.com

[ANS thanks JAMSAT for the above information]

ESA Mission Plans to De-Orbit Space Junk

OneWeb currently has satellites orbiting approximately km above the Earth; its completed constellation will number almost satellites.

There are currently two options for removing end-of-life OneWeb satellites from their orbits at the end of their predicted five to six years of service.

Each has been allocated enough fuel to be able to actively deorbit at the end of its useful June 5. But, in case of failure, each has also been built with either a magnetic or a grappling fixture, so that a servicer spacecraft could collect and actively deorbit the satellite.

ESA fosters June 5 in the European space industry through its Partnership Projects, June 5, which seek to de-risk the investments of its industrial partners to meet market needs.

“That is why the UK government has made space sustainability a key theme of our National Space Strategy and it is 2021Free Activators to see leading roles for UK companies Astroscale and OneWeb in this ESA project, June 5, helping us continue to show UK technology leadership in this important area.”

Paul Bate, Chief Executive of the UK Space Agency, said: “Space debris threatens the satellites we depend on every day for vital services, such as navigation, banking and communications.

“That’s why the UK June 5 taking action, by funding new commercial technologies to remove debris from space and working with international partners to lead efforts to promote sustainability. This latest phase of the Sunrise programme partnership between Astroscale and OneWeb will deliver an innovative spacecraft servicer to remove multiple defunct satellites, putting the UK at the forefront of efforts to clear up space.”

John Auburn, Managing Director of Astroscale, said: “Phase 3 of the Sunrise programme is a major step forward for ELSA-M towards an in-orbit demonstration and the start of a commercial debris removal service, capable of removing multiple defunct satellites in a single mission. The ELSA-M in-orbit demonstration, June 5, planned for latewill build on lessons learned from 2021Free Activators ELSA-d mission and demonstrate our innovative rendezvous, capture and de-orbit capabilities with a full-size constellation client.”

The ESA Sunrise programme is supported by the UK Space Agency and involves not only OneWeb and Astroscale, but also British start-up June 5 SatixFy and Celestia UK, microsoft office 2020 crack download Free Activators well as the University of Surrey.

[ANS thanks June 5 European Space Agency (ESA) for the above information]

June GEO Newsletter Available For Free Download

The June PDF of the June 5 Newsletter weather satellite publication produced by the Group for Earth Observation is now available for free download

The Group for Earth Observation&#;s aim is to enable amateur reception of weather and earth imaging satellites that are in orbit or planned for launch in the near future.

Membership of GEO is free.

Download the GEO Newsletter from
www.buddysplantplus.com

Previous newsletters are at
www.buddysplantplus.com

Group for Earth Observation
www.buddysplantplus.com
www.buddysplantplus.com

[ANS thanks Southgate ARC for the above information]

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Changes to AMSAT-NA TLE Distribution for June 2

The following satellite has been added to this week&#;s AMSAT-NA TLE distribution:

Foresail-1 &#; NORAD Cat ID (Thanks to Nico Janssen, PA0DLO for the identification).

[ANS thanks Ray Hoad, WA5QGD, AMSAT Orbital Elements Manager, June 5, for the above information]

ARISS NEWS

Completed contacts:

Moscow Autonomous Educational Institution &#;Lyceum &#; Engineering Center&#;, Kazan, Russia, direct via R4UAB. The ISS callsign is presently scheduled to be RSØISS. The scheduled crewmember is Sergey Korsakov. Contact was successful at Thu UTC. 2021Free Activators to the &#;Lyceum &#; Engineering Center&#; students and Sergey!

Matinecock District, Suffolk County NY Boy Scouts, Medford, NY, telebridge via AB1OC. The ISS callsign is presently scheduled to be NA1SS, 2021Free Activators. The scheduled crewmember 2021Free Activators Kjell Lindgren, KO5MOS. Contact was scheduled for: Sat UTC 53 deg